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KMID : 0606320080240010011
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Journal of Phamacetical Sciences Sookmyung Women s University
2008 Volume.24 No. 1 p.11 ~ p.14
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Effects of Carboxyethylgermanium Sesquioxide on the Carbon Clearance Activity of Macrophage in Mice
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Oh Hyun-Jeong
Pyo Myoung-Yun
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Abstract
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Effects of carboxyethylgermanium sesquioxide (Ge-132) on the carbon clearance activity of macrophage in blood were investigated in mice. Ge-132 was orally administered with a single dose of 300, 600, 900 mg/kg b.w. to normal and CY-treated ICR mice. Cyclophosphamide (CY) was injected i.p. to mice with a single dose of 20 mg/kg b.w. on the same day of Ge-132 administration. Carbon suspension was injected i.v. at 0.01 ml/g b.w. in mice 48hrs after the administration of experimental chemicals. Blood was collected from retro-orbital venous plexus of mice 5min, 10min after injection of carbon suspension and carbon clearance (t½, min) was assessed. The treatment of Ge-132 alone significantly increased carbon clearance activity of circulating macrophage when compared with control group. Carbon clearance activity was significantly enhanced in the treatment of Ge-132 plus CY when compared with the treatment of CY alone. These results indicate that Ge-132 seemed to significantly restore the reduction of phagocytic activity induced by CY.
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KEYWORD
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Ge-132, macrophage, carbon clearance activity
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